Sex hormone associations with breast cancer risk and the mediation of randomized trial postmenopausal hormone therapy effects
Identifieur interne : 001358 ( Main/Exploration ); précédent : 001357; suivant : 001359Sex hormone associations with breast cancer risk and the mediation of randomized trial postmenopausal hormone therapy effects
Auteurs : Shanshan Zhao [États-Unis] ; Rowan T. Chlebowski [États-Unis] ; Garnet L. Anderson [États-Unis] ; Lewis H. Kuller [États-Unis] ; Joann E. Manson [États-Unis] ; Margery Gass [États-Unis] ; Ruth Patterson [États-Unis] ; Thomas E. Rohan [États-Unis] ; Dorothy S. Lane [États-Unis] ; Shirley Aa Beresford [États-Unis] ; Sayeh Lavasani [États-Unis] ; Jacques E. Rossouw [États-Unis] ; Ross L. Prentice [États-Unis]Source :
- Breast Cancer Research : BCR [ 1465-5411 ] ; 2014.
Abstract
Paradoxically, a breast cancer risk reduction with conjugated equine estrogens (CEE) and a risk elevation with CEE plus medroxyprogesterone acetate (CEE + MPA) were observed in the Women’s Health Initiative (WHI) randomized controlled trials. The effects of hormone therapy on serum sex hormone levels, and on the association between baseline sex hormones and disease risk, may help explain these divergent breast cancer findings.
Serum sex hormone concentrations were measured for 348 breast cancer cases in the CEE + MPA trial and for 235 cases in the CEE trial along with corresponding pair-matched controls, nested within the WHI trials of healthy postmenopausal women. Association and mediation analyses, to examine the extent to which sex hormone levels and changes can explain the breast cancer findings, were conducted using logistic regression.
Following CEE treatment, breast cancer risk was associated with higher concentrations of baseline serum estrogens, and with lower concentrations of sex hormone binding globulin. However, following CEE + MPA, there was no association of breast cancer risk with baseline sex hormone levels. The sex hormone changes from baseline to year 1 provided an explanation for much of the reduced breast cancer risk with CEE. Specifically, the treatment odds ratio (95% confidence interval) increased from 0.71 (0.43, 1.15) to 0.92 (0.41, 2.09) when the year 1 measures were included in the logistic regression analysis. In comparison, the CEE + MPA odds ratio was essentially unchanged when these year 1 measures were included.
Breast cancer risk remains low following CEE use among women having favorable baseline sex hormone profiles, but CEE + MPA evidently produces a breast cancer risk for all women similar to that for women having an unfavorable baseline sex hormone profile. These patterns could reflect breast ductal epithelial cell stimulation by CEE + MPA that is substantially avoided with CEE, in conjunction with relatively more favorable effects of either regimen following a sustained period of estrogen deprivation. These findings may have implications for other hormone therapy formulations and routes of delivery.
clinicaltrials.gov identifier:
Url:
DOI: 10.1186/bcr3632
PubMed: 24670297
PubMed Central: 4053241
Affiliations:
- États-Unis
- Californie, Maryland, Massachusetts, Michigan, Ohio, Pennsylvanie, Washington (État), État de New York
- Pittsburgh, Seattle
- Université de Pittsburgh, Université de Washington
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000753
- to stream Pmc, to step Curation: 000729
- to stream Pmc, to step Checkpoint: 000615
- to stream Ncbi, to step Merge: 001804
- to stream Ncbi, to step Curation: 001804
- to stream Ncbi, to step Checkpoint: 001804
- to stream Main, to step Merge: 001392
- to stream Main, to step Curation: 001358
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Sex hormone associations with breast cancer risk and the mediation of randomized trial postmenopausal hormone therapy effects</title><author><name sortKey="Zhao, Shanshan" sort="Zhao, Shanshan" uniqKey="Zhao S" first="Shanshan" last="Zhao">Shanshan Zhao</name><affiliation wicri:level="1"><nlm:aff id="I1">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, P.O. Box 19024, Seattle WA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, P.O. Box 19024, Seattle WA</wicri:regionArea><wicri:noRegion>Seattle WA</wicri:noRegion></affiliation></author><author><name sortKey="Chlebowski, Rowan T" sort="Chlebowski, Rowan T" uniqKey="Chlebowski R" first="Rowan T" last="Chlebowski">Rowan T. Chlebowski</name><affiliation wicri:level="2"><nlm:aff id="I2">Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Anderson, Garnet L" sort="Anderson, Garnet L" uniqKey="Anderson G" first="Garnet L" last="Anderson">Garnet L. Anderson</name><affiliation wicri:level="1"><nlm:aff id="I1">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, P.O. Box 19024, Seattle WA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, P.O. Box 19024, Seattle WA</wicri:regionArea><wicri:noRegion>Seattle WA</wicri:noRegion></affiliation></author><author><name sortKey="Kuller, Lewis H" sort="Kuller, Lewis H" uniqKey="Kuller L" first="Lewis H" last="Kuller">Lewis H. Kuller</name><affiliation wicri:level="4"><nlm:aff id="I3">Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of Pittsburgh, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Manson, Joann E" sort="Manson, Joann E" uniqKey="Manson J" first="Joann E" last="Manson">Joann E. Manson</name><affiliation wicri:level="2"><nlm:aff id="I4">Division of Preventive Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Preventive Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Gass, Margery" sort="Gass, Margery" uniqKey="Gass M" first="Margery" last="Gass">Margery Gass</name><affiliation wicri:level="2"><nlm:aff id="I5">University Hospital Menopause and Osteoporosis Center, University of Cincinnati, Cincinnati, OH, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University Hospital Menopause and Osteoporosis Center, University of Cincinnati, Cincinnati, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Patterson, Ruth" sort="Patterson, Ruth" uniqKey="Patterson R" first="Ruth" last="Patterson">Ruth Patterson</name><affiliation wicri:level="2"><nlm:aff id="I6">Department of Family and Preventive Medicine, University of California at San Diego, San Diego, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Family and Preventive Medicine, University of California at San Diego, San Diego, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Rohan, Thomas E" sort="Rohan, Thomas E" uniqKey="Rohan T" first="Thomas E" last="Rohan">Thomas E. Rohan</name><affiliation wicri:level="2"><nlm:aff id="I7">Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Lane, Dorothy S" sort="Lane, Dorothy S" uniqKey="Lane D" first="Dorothy S" last="Lane">Dorothy S. Lane</name><affiliation wicri:level="2"><nlm:aff id="I8">Department of Preventive Medicine, State University of New York, Stony Brook, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, State University of New York, Stony Brook, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Beresford, Shirley Aa" sort="Beresford, Shirley Aa" uniqKey="Beresford S" first="Shirley Aa" last="Beresford">Shirley Aa Beresford</name><affiliation wicri:level="4"><nlm:aff id="I9">Department of Epidemiology, University of Washington, Seattle, WA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, University of Washington, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Lavasani, Sayeh" sort="Lavasani, Sayeh" uniqKey="Lavasani S" first="Sayeh" last="Lavasani">Sayeh Lavasani</name><affiliation wicri:level="2"><nlm:aff id="I10">Department of Oncology, Karmanos Cancer Center, Detroit, MI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Oncology, Karmanos Cancer Center, Detroit, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Rossouw, Jacques E" sort="Rossouw, Jacques E" uniqKey="Rossouw J" first="Jacques E" last="Rossouw">Jacques E. Rossouw</name><affiliation wicri:level="2"><nlm:aff id="I11">National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Prentice, Ross L" sort="Prentice, Ross L" uniqKey="Prentice R" first="Ross L" last="Prentice">Ross L. Prentice</name><affiliation wicri:level="1"><nlm:aff id="I1">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, P.O. Box 19024, Seattle WA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, P.O. Box 19024, Seattle WA</wicri:regionArea><wicri:noRegion>Seattle WA</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24670297</idno><idno type="pmc">4053241</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053241</idno><idno type="RBID">PMC:4053241</idno><idno type="doi">10.1186/bcr3632</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000753</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000753</idno><idno type="wicri:Area/Pmc/Curation">000729</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000729</idno><idno type="wicri:Area/Pmc/Checkpoint">000615</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000615</idno><idno type="wicri:Area/Ncbi/Merge">001804</idno><idno type="wicri:Area/Ncbi/Curation">001804</idno><idno type="wicri:Area/Ncbi/Checkpoint">001804</idno><idno type="wicri:doubleKey">1465-5411:2014:Zhao S:sex:hormone:associations</idno><idno type="wicri:Area/Main/Merge">001392</idno><idno type="wicri:Area/Main/Curation">001358</idno><idno type="wicri:Area/Main/Exploration">001358</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Sex hormone associations with breast cancer risk and the mediation of randomized trial postmenopausal hormone therapy effects</title><author><name sortKey="Zhao, Shanshan" sort="Zhao, Shanshan" uniqKey="Zhao S" first="Shanshan" last="Zhao">Shanshan Zhao</name><affiliation wicri:level="1"><nlm:aff id="I1">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, P.O. Box 19024, Seattle WA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, P.O. Box 19024, Seattle WA</wicri:regionArea><wicri:noRegion>Seattle WA</wicri:noRegion></affiliation></author><author><name sortKey="Chlebowski, Rowan T" sort="Chlebowski, Rowan T" uniqKey="Chlebowski R" first="Rowan T" last="Chlebowski">Rowan T. Chlebowski</name><affiliation wicri:level="2"><nlm:aff id="I2">Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Anderson, Garnet L" sort="Anderson, Garnet L" uniqKey="Anderson G" first="Garnet L" last="Anderson">Garnet L. Anderson</name><affiliation wicri:level="1"><nlm:aff id="I1">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, P.O. Box 19024, Seattle WA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, P.O. Box 19024, Seattle WA</wicri:regionArea><wicri:noRegion>Seattle WA</wicri:noRegion></affiliation></author><author><name sortKey="Kuller, Lewis H" sort="Kuller, Lewis H" uniqKey="Kuller L" first="Lewis H" last="Kuller">Lewis H. Kuller</name><affiliation wicri:level="4"><nlm:aff id="I3">Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of Pittsburgh, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Manson, Joann E" sort="Manson, Joann E" uniqKey="Manson J" first="Joann E" last="Manson">Joann E. Manson</name><affiliation wicri:level="2"><nlm:aff id="I4">Division of Preventive Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Preventive Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Gass, Margery" sort="Gass, Margery" uniqKey="Gass M" first="Margery" last="Gass">Margery Gass</name><affiliation wicri:level="2"><nlm:aff id="I5">University Hospital Menopause and Osteoporosis Center, University of Cincinnati, Cincinnati, OH, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University Hospital Menopause and Osteoporosis Center, University of Cincinnati, Cincinnati, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Patterson, Ruth" sort="Patterson, Ruth" uniqKey="Patterson R" first="Ruth" last="Patterson">Ruth Patterson</name><affiliation wicri:level="2"><nlm:aff id="I6">Department of Family and Preventive Medicine, University of California at San Diego, San Diego, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Family and Preventive Medicine, University of California at San Diego, San Diego, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Rohan, Thomas E" sort="Rohan, Thomas E" uniqKey="Rohan T" first="Thomas E" last="Rohan">Thomas E. Rohan</name><affiliation wicri:level="2"><nlm:aff id="I7">Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Lane, Dorothy S" sort="Lane, Dorothy S" uniqKey="Lane D" first="Dorothy S" last="Lane">Dorothy S. Lane</name><affiliation wicri:level="2"><nlm:aff id="I8">Department of Preventive Medicine, State University of New York, Stony Brook, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, State University of New York, Stony Brook, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Beresford, Shirley Aa" sort="Beresford, Shirley Aa" uniqKey="Beresford S" first="Shirley Aa" last="Beresford">Shirley Aa Beresford</name><affiliation wicri:level="4"><nlm:aff id="I9">Department of Epidemiology, University of Washington, Seattle, WA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, University of Washington, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Lavasani, Sayeh" sort="Lavasani, Sayeh" uniqKey="Lavasani S" first="Sayeh" last="Lavasani">Sayeh Lavasani</name><affiliation wicri:level="2"><nlm:aff id="I10">Department of Oncology, Karmanos Cancer Center, Detroit, MI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Oncology, Karmanos Cancer Center, Detroit, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Rossouw, Jacques E" sort="Rossouw, Jacques E" uniqKey="Rossouw J" first="Jacques E" last="Rossouw">Jacques E. Rossouw</name><affiliation wicri:level="2"><nlm:aff id="I11">National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Prentice, Ross L" sort="Prentice, Ross L" uniqKey="Prentice R" first="Ross L" last="Prentice">Ross L. Prentice</name><affiliation wicri:level="1"><nlm:aff id="I1">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, P.O. Box 19024, Seattle WA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, P.O. Box 19024, Seattle WA</wicri:regionArea><wicri:noRegion>Seattle WA</wicri:noRegion></affiliation></author></analytic><series><title level="j">Breast Cancer Research : BCR</title><idno type="ISSN">1465-5411</idno><idno type="eISSN">1465-542X</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Introduction</title><p>Paradoxically, a breast cancer risk reduction with conjugated equine estrogens (CEE) and a risk elevation with CEE plus medroxyprogesterone acetate (CEE + MPA) were observed in the Women’s Health Initiative (WHI) randomized controlled trials. The effects of hormone therapy on serum sex hormone levels, and on the association between baseline sex hormones and disease risk, may help explain these divergent breast cancer findings.</p></sec><sec><title>Methods</title><p>Serum sex hormone concentrations were measured for 348 breast cancer cases in the CEE + MPA trial and for 235 cases in the CEE trial along with corresponding pair-matched controls, nested within the WHI trials of healthy postmenopausal women. Association and mediation analyses, to examine the extent to which sex hormone levels and changes can explain the breast cancer findings, were conducted using logistic regression.</p></sec><sec><title>Results</title><p>Following CEE treatment, breast cancer risk was associated with higher concentrations of baseline serum estrogens, and with lower concentrations of sex hormone binding globulin. However, following CEE + MPA, there was no association of breast cancer risk with baseline sex hormone levels. The sex hormone changes from baseline to year 1 provided an explanation for much of the reduced breast cancer risk with CEE. Specifically, the treatment odds ratio (95% confidence interval) increased from 0.71 (0.43, 1.15) to 0.92 (0.41, 2.09) when the year 1 measures were included in the logistic regression analysis. In comparison, the CEE + MPA odds ratio was essentially unchanged when these year 1 measures were included.</p></sec><sec><title>Conclusions</title><p>Breast cancer risk remains low following CEE use among women having favorable baseline sex hormone profiles, but CEE + MPA evidently produces a breast cancer risk for all women similar to that for women having an unfavorable baseline sex hormone profile. These patterns could reflect breast ductal epithelial cell stimulation by CEE + MPA that is substantially avoided with CEE, in conjunction with relatively more favorable effects of either regimen following a sustained period of estrogen deprivation. These findings may have implications for other hormone therapy formulations and routes of delivery.</p></sec><sec><title>Trial registration</title><p>clinicaltrials.gov identifier:
<ext-link ext-link-type="uri" xlink:href="http://www.clinicaltrials.gov/">NCT00000611</ext-link>.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Chlebowski, Rt" uniqKey="Chlebowski R">RT Chlebowski</name></author><author><name sortKey="Hendrix, Sl" uniqKey="Hendrix S">SL Hendrix</name></author><author><name sortKey="Langer, Rd" uniqKey="Langer R">RD Langer</name></author><author><name sortKey="Stefanick, Ml" uniqKey="Stefanick M">ML Stefanick</name></author><author><name sortKey="Gass, M" uniqKey="Gass M">M Gass</name></author><author><name sortKey="Lane, D" uniqKey="Lane D">D Lane</name></author><author><name sortKey="Rodabough, Rj" uniqKey="Rodabough R">RJ Rodabough</name></author><author><name sortKey="Gilligan, Ma" uniqKey="Gilligan M">MA Gilligan</name></author><author><name sortKey="Cyr, Mg" uniqKey="Cyr M">MG Cyr</name></author><author><name sortKey="Thomson, Ca" uniqKey="Thomson C">CA Thomson</name></author><author><name sortKey="Khandekar, J" uniqKey="Khandekar J">J Khandekar</name></author><author><name sortKey="Petrovitch, H" uniqKey="Petrovitch H">H Petrovitch</name></author><author><name sortKey="Mctiernan, A" uniqKey="Mctiernan A">A McTiernan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chlebowski, Rt" uniqKey="Chlebowski R">RT Chlebowski</name></author><author><name sortKey="Kuller, Lh" uniqKey="Kuller L">LH Kuller</name></author><author><name sortKey="Prentice, Rl" uniqKey="Prentice R">RL Prentice</name></author><author><name sortKey="Stefanick, Ml" uniqKey="Stefanick M">ML Stefanick</name></author><author><name sortKey="Manson, Je" uniqKey="Manson J">JE Manson</name></author><author><name sortKey="Gass, M" uniqKey="Gass M">M Gass</name></author><author><name sortKey="Aragaki, Ak" uniqKey="Aragaki A">AK Aragaki</name></author><author><name sortKey="Ockene, Jk" uniqKey="Ockene J">JK Ockene</name></author><author><name sortKey="Lane, Ds" uniqKey="Lane D">DS Lane</name></author><author><name sortKey="Sarto, Ge" uniqKey="Sarto G">GE Sarto</name></author><author><name sortKey="Rajkovic, A" uniqKey="Rajkovic A">A Rajkovic</name></author><author><name sortKey="Schenken, R" uniqKey="Schenken R">R Schenken</name></author><author><name sortKey="Hendrix, Sl" uniqKey="Hendrix S">SL Hendrix</name></author><author><name sortKey="Ravdin, Pm" uniqKey="Ravdin P">PM Ravdin</name></author><author><name sortKey="Rohan, Te" uniqKey="Rohan T">TE Rohan</name></author><author><name sortKey="Yasmeen, S" uniqKey="Yasmeen S">S Yasmeen</name></author><author><name sortKey="Anderson, G" uniqKey="Anderson G">G Anderson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chlebowski, Rt" uniqKey="Chlebowski R">RT Chlebowski</name></author><author><name sortKey="Anderson, Gl" uniqKey="Anderson G">GL Anderson</name></author><author><name sortKey="Gass, M" uniqKey="Gass M">M Gass</name></author><author><name sortKey="Lane, Ds" uniqKey="Lane D">DS Lane</name></author><author><name sortKey="Aragaki, Ak" uniqKey="Aragaki A">AK Aragaki</name></author><author><name sortKey="Kuller, Lh" uniqKey="Kuller L">LH Kuller</name></author><author><name sortKey="Manson, Je" uniqKey="Manson J">JE Manson</name></author><author><name sortKey="Stefanick, Ml" uniqKey="Stefanick M">ML Stefanick</name></author><author><name sortKey="Ockene, J" uniqKey="Ockene J">J Ockene</name></author><author><name sortKey="Sarto, Ge" uniqKey="Sarto G">GE Sarto</name></author><author><name sortKey="Johnson, Kc" uniqKey="Johnson K">KC Johnson</name></author><author><name sortKey="Wactawski Wende, J" uniqKey="Wactawski Wende J">J Wactawski-Wende</name></author><author><name sortKey="Ravdin, Pm" uniqKey="Ravdin P">PM Ravdin</name></author><author><name sortKey="Schenken, R" uniqKey="Schenken R">R Schenken</name></author><author><name sortKey="Hendrix, Sl" uniqKey="Hendrix S">SL Hendrix</name></author><author><name sortKey="Rajkovic, A" uniqKey="Rajkovic A">A Rajkovic</name></author><author><name sortKey="Rohan, Te" uniqKey="Rohan T">TE Rohan</name></author><author><name sortKey="Yasmeen, S" uniqKey="Yasmeen S">S Yasmeen</name></author><author><name sortKey="Prentice, Rl" uniqKey="Prentice R">RL Prentice</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Stefanick, Ml" uniqKey="Stefanick M">ML Stefanick</name></author><author><name sortKey="Anderson, Gl" uniqKey="Anderson G">GL Anderson</name></author><author><name sortKey="Margolis, Kl" uniqKey="Margolis K">KL Margolis</name></author><author><name sortKey="Hendrix, Sl" uniqKey="Hendrix S">SL Hendrix</name></author><author><name sortKey="Rodabough, Rj" uniqKey="Rodabough R">RJ Rodabough</name></author><author><name sortKey="Paskett, Ed" uniqKey="Paskett E">ED Paskett</name></author><author><name sortKey="Lane, Ds" uniqKey="Lane D">DS Lane</name></author><author><name sortKey="Hubbell, Fa" uniqKey="Hubbell F">FA Hubbell</name></author><author><name sortKey="Assaf, Ar" uniqKey="Assaf A">AR Assaf</name></author><author><name sortKey="Sarto, Ge" uniqKey="Sarto G">GE Sarto</name></author><author><name sortKey="Schenken, Rs" uniqKey="Schenken R">RS Schenken</name></author><author><name sortKey="Yasmeen, S" uniqKey="Yasmeen S">S Yasmeen</name></author><author><name sortKey="Lessin, L" uniqKey="Lessin L">L Lessin</name></author><author><name sortKey="Chlebowski, Rt" uniqKey="Chlebowski R">RT Chlebowski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Anderson, Gl" uniqKey="Anderson G">GL Anderson</name></author><author><name sortKey="Chlebowski, Rt" uniqKey="Chlebowski R">RT Chlebowski</name></author><author><name sortKey="Aragaki, Ak" uniqKey="Aragaki A">AK Aragaki</name></author><author><name sortKey="Kuller, Lh" uniqKey="Kuller L">LH Kuller</name></author><author><name sortKey="Manson, Je" uniqKey="Manson J">JE Manson</name></author><author><name sortKey="Gass, M" uniqKey="Gass M">M Gass</name></author><author><name sortKey="Bluhm, E" uniqKey="Bluhm E">E Bluhm</name></author><author><name sortKey="Connelly, S" uniqKey="Connelly S">S Connelly</name></author><author><name sortKey="Hubbell, Fa" uniqKey="Hubbell F">FA Hubbell</name></author><author><name sortKey="Lane, D" uniqKey="Lane D">D Lane</name></author><author><name sortKey="Martin, L" uniqKey="Martin L">L Martin</name></author><author><name sortKey="Ockene, J" uniqKey="Ockene J">J Ockene</name></author><author><name sortKey="Rohan, T" uniqKey="Rohan T">T Rohan</name></author><author><name sortKey="Schenken, R" uniqKey="Schenken R">R Schenken</name></author><author><name sortKey="Wactawski Wende, J" uniqKey="Wactawski Wende J">J Wactawski-Wende</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Prentice, Rl" uniqKey="Prentice R">RL Prentice</name></author><author><name sortKey="Chlebowski, Rt" uniqKey="Chlebowski R">RT Chlebowski</name></author><author><name sortKey="Stefanick, Ml" uniqKey="Stefanick M">ML Stefanick</name></author><author><name sortKey="Manson, Je" uniqKey="Manson J">JE Manson</name></author><author><name sortKey="Pettinger, M" uniqKey="Pettinger M">M Pettinger</name></author><author><name sortKey="Hendrix, Sl" uniqKey="Hendrix S">SL Hendrix</name></author><author><name sortKey="Hubbell, Fa" uniqKey="Hubbell F">FA Hubbell</name></author><author><name sortKey="Kooperberg, C" uniqKey="Kooperberg C">C Kooperberg</name></author><author><name sortKey="Kuller, Lh" uniqKey="Kuller L">LH Kuller</name></author><author><name sortKey="Lane, Ds" uniqKey="Lane D">DS Lane</name></author><author><name sortKey="Mctiernan, A" uniqKey="Mctiernan A">A McTiernan</name></author><author><name sortKey="O Ullivan, Mj" uniqKey="O Ullivan M">MJ O’Sullivan</name></author><author><name sortKey="Rossouw, Je" uniqKey="Rossouw J">JE Rossouw</name></author><author><name sortKey="Anderson, Gl" uniqKey="Anderson G">GL Anderson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Prentice, Rl" uniqKey="Prentice R">RL Prentice</name></author><author><name sortKey="Chlebowski, Rt" uniqKey="Chlebowski R">RT Chlebowski</name></author><author><name sortKey="Stefanick, Ml" uniqKey="Stefanick M">ML Stefanick</name></author><author><name sortKey="Manson, Je" uniqKey="Manson J">JE Manson</name></author><author><name sortKey="Langer, Rd" uniqKey="Langer R">RD Langer</name></author><author><name sortKey="Pettinger, M" uniqKey="Pettinger M">M Pettinger</name></author><author><name sortKey="Hendrix, Sl" uniqKey="Hendrix S">SL Hendrix</name></author><author><name sortKey="Hubbell, Fa" uniqKey="Hubbell F">FA Hubbell</name></author><author><name sortKey="Kooperberg, C" uniqKey="Kooperberg C">C Kooperberg</name></author><author><name sortKey="Kuller, Lh" uniqKey="Kuller L">LH Kuller</name></author><author><name sortKey="Lane, Ds" uniqKey="Lane D">DS Lane</name></author><author><name sortKey="Mctiernan, A" uniqKey="Mctiernan A">A McTiernan</name></author><author><name sortKey="O Ullivan, Mj" uniqKey="O Ullivan M">MJ O’Sullivan</name></author><author><name sortKey="Rossouw, Je" uniqKey="Rossouw J">JE Rossouw</name></author><author><name sortKey="Anderson, Gl" uniqKey="Anderson G">GL Anderson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Beral, V" uniqKey="Beral V">V Beral</name></author><author><name sortKey="Reeves, G" uniqKey="Reeves G">G Reeves</name></author><author><name sortKey="Bull, D" uniqKey="Bull D">D Bull</name></author><author><name sortKey="Green, J" uniqKey="Green J">J Green</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Manson, Je" uniqKey="Manson J">JE Manson</name></author><author><name sortKey="Chlebowski, Rt" uniqKey="Chlebowski R">RT Chlebowski</name></author><author><name sortKey="Stefanick, Ml" uniqKey="Stefanick M">ML Stefanick</name></author><author><name sortKey="Aragaki, Ak" uniqKey="Aragaki A">AK Aragaki</name></author><author><name sortKey="Rossouw, Je" uniqKey="Rossouw J">JE Rossouw</name></author><author><name sortKey="Prentice, Rl" uniqKey="Prentice R">RL Prentice</name></author><author><name sortKey="Anderson, G" uniqKey="Anderson G">G Anderson</name></author><author><name sortKey="Howard, Bv" uniqKey="Howard B">BV Howard</name></author><author><name sortKey="Thomson, Ca" uniqKey="Thomson C">CA Thomson</name></author><author><name sortKey="Lacroix, Az" uniqKey="Lacroix A">AZ LaCroix</name></author><author><name sortKey="Wactawski Wende, J" uniqKey="Wactawski Wende J">J Wactawski-Wende</name></author><author><name sortKey="Jackson, Rd" uniqKey="Jackson R">RD Jackson</name></author><author><name sortKey="Limacher, M" uniqKey="Limacher M">M Limacher</name></author><author><name sortKey="Margolis, Kl" uniqKey="Margolis K">KL Margolis</name></author><author><name sortKey="Wassertheil Smoller, S" uniqKey="Wassertheil Smoller S">S Wassertheil-Smoller</name></author><author><name sortKey="Beresford, Sa" uniqKey="Beresford S">SA Beresford</name></author><author><name sortKey="Cauley, Ja" uniqKey="Cauley J">JA Cauley</name></author><author><name sortKey="Eaton, Cb" uniqKey="Eaton C">CB Eaton</name></author><author><name sortKey="Gass, M" uniqKey="Gass M">M Gass</name></author><author><name sortKey="Hsia, J" uniqKey="Hsia J">J Hsia</name></author><author><name sortKey="Johnson, Kc" uniqKey="Johnson K">KC Johnson</name></author><author><name sortKey="Kooperberg, C" uniqKey="Kooperberg C">C Kooperberg</name></author><author><name sortKey="Kuller, Lh" uniqKey="Kuller L">LH Kuller</name></author><author><name sortKey="Lewis, Ce" uniqKey="Lewis C">CE Lewis</name></author><author><name sortKey="Liu, S" uniqKey="Liu S">S Liu</name></author><author><name sortKey="Martin, Lw" uniqKey="Martin L">LW Martin</name></author><author><name sortKey="Ockene, Jk" uniqKey="Ockene J">JK Ockene</name></author><author><name sortKey="O Ullivan, Mj" uniqKey="O Ullivan M">MJ O’Sullivan</name></author><author><name sortKey="Powell, L" uniqKey="Powell L">L Powell</name></author><author><name sortKey="Simon, Ms" uniqKey="Simon M">MS Simon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Edlefsen, Kl" uniqKey="Edlefsen K">KL Edlefsen</name></author><author><name sortKey="Jackson, Rd" uniqKey="Jackson R">RD Jackson</name></author><author><name sortKey="Prentice, Rl" uniqKey="Prentice R">RL Prentice</name></author><author><name sortKey="Janssen, I" uniqKey="Janssen I">I Janssen</name></author><author><name sortKey="Rajkovic, A" uniqKey="Rajkovic A">A Rajkovic</name></author><author><name sortKey="O Ullivan, Mj" uniqKey="O Ullivan M">MJ O’Sullivan</name></author><author><name sortKey="Anderson, G" uniqKey="Anderson G">G Anderson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Farhat, Gn" uniqKey="Farhat G">GN Farhat</name></author><author><name sortKey="Parimi, N" uniqKey="Parimi N">N Parimi</name></author><author><name sortKey="Chlebowski, Rt" uniqKey="Chlebowski R">RT Chlebowski</name></author><author><name sortKey="Manson, Je" uniqKey="Manson J">JE Manson</name></author><author><name sortKey="Anderson, G" uniqKey="Anderson G">G Anderson</name></author><author><name sortKey="Huang, Aj" uniqKey="Huang A">AJ Huang</name></author><author><name sortKey="Vittinghoff, E" uniqKey="Vittinghoff E">E Vittinghoff</name></author><author><name sortKey="Lee, Js" uniqKey="Lee J">JS Lee</name></author><author><name sortKey="Lacroix, Az" uniqKey="Lacroix A">AZ Lacroix</name></author><author><name sortKey="Cauley, Ja" uniqKey="Cauley J">JA Cauley</name></author><author><name sortKey="Jackson, R" uniqKey="Jackson R">R Jackson</name></author><author><name sortKey="Grady, D" uniqKey="Grady D">D Grady</name></author><author><name sortKey="Lane, Ds" uniqKey="Lane D">DS Lane</name></author><author><name sortKey="Phillips, L" uniqKey="Phillips L">L Phillips</name></author><author><name sortKey="Simon, Ms" uniqKey="Simon M">MS Simon</name></author><author><name sortKey="Cummings, Sr" uniqKey="Cummings S">SR Cummings</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Hays, J" uniqKey="Hays J">J Hays</name></author><author><name sortKey="Hunt, Jr" uniqKey="Hunt J">JR Hunt</name></author><author><name sortKey="Hubbell, Fa" uniqKey="Hubbell F">FA Hubbell</name></author><author><name sortKey="Anderson, Gl" uniqKey="Anderson G">GL Anderson</name></author><author><name sortKey="Limacher, M" uniqKey="Limacher M">M Limacher</name></author><author><name sortKey="Allen, C" uniqKey="Allen C">C Allen</name></author><author><name sortKey="Rossouw, Je" uniqKey="Rossouw J">JE Rossouw</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Curb, Jd" uniqKey="Curb J">JD Curb</name></author><author><name sortKey="Mctiernan, A" uniqKey="Mctiernan A">A McTiernan</name></author><author><name sortKey="Heckbert, Sr" uniqKey="Heckbert S">SR Heckbert</name></author><author><name sortKey="Kooperberg, C" uniqKey="Kooperberg C">C Kooperberg</name></author><author><name sortKey="Stanford, J" uniqKey="Stanford J">J Stanford</name></author><author><name sortKey="Nevitt, M" uniqKey="Nevitt M">M Nevitt</name></author><author><name sortKey="Johnson, Kc" uniqKey="Johnson K">KC Johnson</name></author><author><name sortKey="Proulx Burns, L" uniqKey="Proulx Burns L">L Proulx-Burns</name></author><author><name sortKey="Pastore, L" uniqKey="Pastore L">L Pastore</name></author><author><name sortKey="Criqui, M" uniqKey="Criqui M">M Criqui</name></author><author><name sortKey="Daugherty, S" uniqKey="Daugherty S">S Daugherty</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Anderson, Gl" uniqKey="Anderson G">GL Anderson</name></author><author><name sortKey="Manson, J" uniqKey="Manson J">J Manson</name></author><author><name sortKey="Wallace, R" uniqKey="Wallace R">R Wallace</name></author><author><name sortKey="Lund, B" uniqKey="Lund B">B Lund</name></author><author><name sortKey="Hall, D" uniqKey="Hall D">D Hall</name></author><author><name sortKey="Davis, S" uniqKey="Davis S">S Davis</name></author><author><name sortKey="Shumaker, S" uniqKey="Shumaker S">S Shumaker</name></author><author><name sortKey="Wang, Cy" uniqKey="Wang C">CY Wang</name></author><author><name sortKey="Stein, E" uniqKey="Stein E">E Stein</name></author><author><name sortKey="Prentice, Rl" uniqKey="Prentice R">RL Prentice</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Prentice, Rl" uniqKey="Prentice R">RL Prentice</name></author><author><name sortKey="Pyke, R" uniqKey="Pyke R">R Pyke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gail, Mh" uniqKey="Gail M">MH Gail</name></author><author><name sortKey="Brinton, La" uniqKey="Brinton L">LA Brinton</name></author><author><name sortKey="Byar, Dp" uniqKey="Byar D">DP Byar</name></author><author><name sortKey="Corle, Dk" uniqKey="Corle D">DK Corle</name></author><author><name sortKey="Green, Sb" uniqKey="Green S">SB Green</name></author><author><name sortKey="Schairer, C" uniqKey="Schairer C">C Schairer</name></author><author><name sortKey="Mulvihill, Jj" uniqKey="Mulvihill J">JJ Mulvihill</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rosner, B" uniqKey="Rosner B">B Rosner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schindler, Ae" uniqKey="Schindler A">AE Schindler</name></author><author><name sortKey="Campagnoli, C" uniqKey="Campagnoli C">C Campagnoli</name></author><author><name sortKey="Druckmann, R" uniqKey="Druckmann R">R Druckmann</name></author><author><name sortKey="Huber, J" uniqKey="Huber J">J Huber</name></author><author><name sortKey="Pasqualini, Jr" uniqKey="Pasqualini J">JR Pasqualini</name></author><author><name sortKey="Schweppe, Kw" uniqKey="Schweppe K">KW Schweppe</name></author><author><name sortKey="Thijssen, Jh" uniqKey="Thijssen J">JH Thijssen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Obiorah, I" uniqKey="Obiorah I">I Obiorah</name></author><author><name sortKey="Jordan, C" uniqKey="Jordan C">C Jordan</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li><li>Maryland</li><li>Massachusetts</li><li>Michigan</li><li>Ohio</li><li>Pennsylvanie</li><li>Washington (État)</li><li>État de New York</li></region><settlement><li>Pittsburgh</li><li>Seattle</li></settlement><orgName><li>Université de Pittsburgh</li><li>Université de Washington</li></orgName></list><tree><country name="États-Unis"><noRegion><name sortKey="Zhao, Shanshan" sort="Zhao, Shanshan" uniqKey="Zhao S" first="Shanshan" last="Zhao">Shanshan Zhao</name></noRegion><name sortKey="Anderson, Garnet L" sort="Anderson, Garnet L" uniqKey="Anderson G" first="Garnet L" last="Anderson">Garnet L. Anderson</name><name sortKey="Beresford, Shirley Aa" sort="Beresford, Shirley Aa" uniqKey="Beresford S" first="Shirley Aa" last="Beresford">Shirley Aa Beresford</name><name sortKey="Chlebowski, Rowan T" sort="Chlebowski, Rowan T" uniqKey="Chlebowski R" first="Rowan T" last="Chlebowski">Rowan T. Chlebowski</name><name sortKey="Gass, Margery" sort="Gass, Margery" uniqKey="Gass M" first="Margery" last="Gass">Margery Gass</name><name sortKey="Kuller, Lewis H" sort="Kuller, Lewis H" uniqKey="Kuller L" first="Lewis H" last="Kuller">Lewis H. Kuller</name><name sortKey="Lane, Dorothy S" sort="Lane, Dorothy S" uniqKey="Lane D" first="Dorothy S" last="Lane">Dorothy S. Lane</name><name sortKey="Lavasani, Sayeh" sort="Lavasani, Sayeh" uniqKey="Lavasani S" first="Sayeh" last="Lavasani">Sayeh Lavasani</name><name sortKey="Manson, Joann E" sort="Manson, Joann E" uniqKey="Manson J" first="Joann E" last="Manson">Joann E. Manson</name><name sortKey="Patterson, Ruth" sort="Patterson, Ruth" uniqKey="Patterson R" first="Ruth" last="Patterson">Ruth Patterson</name><name sortKey="Prentice, Ross L" sort="Prentice, Ross L" uniqKey="Prentice R" first="Ross L" last="Prentice">Ross L. Prentice</name><name sortKey="Rohan, Thomas E" sort="Rohan, Thomas E" uniqKey="Rohan T" first="Thomas E" last="Rohan">Thomas E. Rohan</name><name sortKey="Rossouw, Jacques E" sort="Rossouw, Jacques E" uniqKey="Rossouw J" first="Jacques E" last="Rossouw">Jacques E. Rossouw</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Amérique/explor/PittsburghV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001358 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001358 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Amérique
|area= PittsburghV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:4053241
|texte= Sex hormone associations with breast cancer risk and the mediation of randomized trial postmenopausal hormone therapy effects
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:24670297" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a PittsburghV1
| This area was generated with Dilib version V0.6.38. |  |